|
| [February 20, 2013] |
 |
Patent for Nano-scale Detection of Ion Channel Function in Lipoparticles
PHILADELPHIA --(Business Wire)--
Integral Molecular, Inc., a leader in membrane protein reagents and
services, announces a patent allowance covering its technology for
cell-free detection of ion channel function. The U.S. patent covers the
application of Integral Molecular's Lipoparticle technology for deriving
high concentrations of functional ion channels for drug screening,
antibody development, and biomedical research. Ion channels are
important therapeutic targets for a wide range of human diseases and
comprise approximately 15% of existing drug targets. Lipoparticle
technology stems from research conducted at the University of
Pennsylvania and published in the journals Science, PNAS,
and Journal of Virology. US Patent No. 8,377,691 was issued by
the U.S. Patent and Trademark Office on February 19, 2013 to Integral
Molecular.
"The Lipoparticle technology overcomes many of the challenges of
conventional electrophysiological approachesfor screening ion channel
targets, which have largely been limited to studies with live cells or
reconstituted lipid bilayers," said Dr. Benjamin Doranz, Chief
Scientific Officer at Integral Molecular and the inventor of the
technology. "Development and validation of the Lipoparticle ion channel
technology enabled Integral Molecular to successfully implement
high-throughput screening (HTS) campaigns against ion channels,
including the identification of novel anti-influenza lead compounds."
Integral Molecular offers custom-produced Lipoparticles with
user-specified membrane proteins, as well as ReadyReceptor®
Lipoparticles that contain pre-validated high-concentration membrane
protein targets such as GPCRs, transporters, and ion channels. Each lot
of Lipoparticles is quality controlled and provided with technical
protocols for relevant applications, including antibody screening,
biosensor assays, ELISA binding assays, and functional assays.
Lipoparticles can be biotinylated or fluorescently labeled to
accommodate specialized applications.
About Integral Molecular
Integral Molecular is a biotechnology company committed to providing
innovative solutions for membrane protein research. The company has been
working with pharmaceutical, biotechnology, and academic customers and
collaborators for over ten years, providing membrane protein related
products and services that advance its customers' scientific objectives.
For more information, visit Integral Molecular's website: www.integralmolecular.com.
[ Back To Homepage ]
|
